diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 89d668d05..376ae8d5f 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -27,17 +27,17 @@ jobs:
     if: "! contains(toJSON(github.event.commits.*.message), '[skip ci]')"
     strategy:
       matrix:
-        python-version: [3.6, 3.7, 3.8, 3.9]
+        python-version: [3.7, 3.8, 3.9]
         platform: [ubuntu-latest, macos-latest, windows-latest]
         exclude: # Only test on the oldest and latest supported stable Python on macOS and Windows.
           - platform: macos-latest
             python-version: 3.7
           - platform: macos-latest
-            python-version: 3.8
+            python-version: 3.9
           - platform: windows-latest
             python-version: 3.7
           - platform: windows-latest
-            python-version: 3.8
+            python-version: 3.9
     steps:
     - uses: actions/checkout@v2
     - name: Set up Python ${{ matrix.python-version }}
diff --git a/README.rst b/README.rst
index 78f422ef2..6f64f5808 100644
--- a/README.rst
+++ b/README.rst
@@ -18,14 +18,8 @@ are available at `Read the Docs <https://fonttools.readthedocs.io/>`_.
 Installation
 ~~~~~~~~~~~~
 
-FontTools 4.x requires `Python <http://www.python.org/download/>`__ 3.6
-or later. FontTools 3.x requires Python 2.7 or later.
-
-**NOTE** From August 2019, until no later than January 1 2020, the support
-for *Python 2.7* will be limited to only critical bug fixes, and no new features
-will be added to the ``py27`` branch. You can read more `here <https://python3statement.org>`__
-and `here <https://github.com/fonttools/fonttools/issues/765>`__ for the
-reasons behind this decision.
+FontTools requires `Python <http://www.python.org/download/>`__ 3.7
+or later.
 
 The package is listed in the Python Package Index (PyPI), so you can
 install it with `pip <https://pip.pypa.io>`__:
diff --git a/Tests/designspaceLib/designspace_test.py b/Tests/designspaceLib/designspace_test.py
index 8daf741d9..b6ee9d655 100644
--- a/Tests/designspaceLib/designspace_test.py
+++ b/Tests/designspaceLib/designspace_test.py
@@ -830,7 +830,6 @@ def test_updatePaths(tmpdir):
     assert s1.filename == name2
 
 
-@pytest.mark.skipif(sys.version_info[:2] < (3, 6), reason="pathlib is only tested on 3.6 and up")
 def test_read_with_path_object():
     import pathlib
     source = (pathlib.Path(__file__) / "../data/test.designspace").resolve()
@@ -839,7 +838,6 @@ def test_read_with_path_object():
     doc.read(source)
 
 
-@pytest.mark.skipif(sys.version_info[:2] < (3, 6), reason="pathlib is only tested on 3.6 and up")
 def test_with_with_path_object(tmpdir):
     import pathlib
     tmpdir = str(tmpdir)
diff --git a/Tests/t1Lib/t1Lib_test.py b/Tests/t1Lib/t1Lib_test.py
index 92b3e9e1c..947582327 100644
--- a/Tests/t1Lib/t1Lib_test.py
+++ b/Tests/t1Lib/t1Lib_test.py
@@ -58,7 +58,6 @@ class ReadWriteTest(unittest.TestCase):
 		data = self.write(font, 'OTHER', dohex=True)
 		self.assertEqual(font.getData(), data)
 
-	@unittest.skipIf(sys.version_info[:2] < (3, 6), "pathlib is only tested on 3.6 and up")
 	def test_read_with_path(self):
 		import pathlib
 		font = t1Lib.T1Font(pathlib.Path(PFB))
diff --git a/mypy.ini b/mypy.ini
index 7e37b03fb..0a04cfb23 100644
--- a/mypy.ini
+++ b/mypy.ini
@@ -1,5 +1,5 @@
 [mypy]
-python_version = 3.6
+python_version = 3.7
 files = Lib/fontTools/misc/plistlib
 follow_imports = silent
 ignore_missing_imports = True
diff --git a/setup.py b/setup.py
index 0f8b4318b..44f2c0579 100755
--- a/setup.py
+++ b/setup.py
@@ -450,7 +450,7 @@ setup_params = dict(
 	url="http://github.com/fonttools/fonttools",
 	license="MIT",
 	platforms=["Any"],
-	python_requires=">=3.6",
+	python_requires=">=3.7",
 	long_description=long_description,
 	package_dir={'': 'Lib'},
 	packages=find_packages("Lib"),
diff --git a/tox.ini b/tox.ini
index bcbeeeddf..a5802a646 100644
--- a/tox.ini
+++ b/tox.ini
@@ -1,6 +1,6 @@
 [tox]
 minversion = 3.0
-envlist = mypy, py3{6,7,8,9}-cov, htmlcov
+envlist = mypy, py3{7,8,9}-cov, htmlcov
 skip_missing_interpreters=true
 
 [testenv]