diff --git a/MANIFEST.in b/MANIFEST.in
index 31a9c256b..8e2bcd1d1 100644
--- a/MANIFEST.in
+++ b/MANIFEST.in
@@ -12,7 +12,6 @@ include Lib/fontTools/ttLib/tables/table_API_readme.txt
 include *requirements.txt
 include tox.ini
 include mypy.ini
-include run-tests.sh
 
 recursive-include Lib/fontTools py.typed
 
diff --git a/Makefile b/Makefile
index b2e3d96b7..21cad6cd2 100644
--- a/Makefile
+++ b/Makefile
@@ -14,7 +14,7 @@ uninstall:
 	pip uninstall --yes fonttools
 
 check: all
-	./run-tests.sh
+	pytest
 
 clean:
 	./setup.py clean --all
diff --git a/run-tests.sh b/run-tests.sh
deleted file mode 100755
index f10c1b01d..000000000
--- a/run-tests.sh
+++ /dev/null
@@ -1,28 +0,0 @@
-#!/bin/sh
-
-# exit if any subcommand return non-zero status
-set -e
-
-# Choose python version
-if test "x$1" = x-3; then
-	PYTHON=py3
-	shift
-elif test "x$1" = x-2; then
-	PYTHON=py2
-	shift
-fi
-test "x$PYTHON" = x && PYTHON=py
-
-# Find tests
-FILTERS=
-for arg in "$@"; do
-	test "x$FILTERS" != x && FILTERS="$FILTERS or "
-	FILTERS="$FILTERS$arg"
-done
-
-# Run tests
-if [ -z "$FILTERS" ]; then
-	tox --develop -e $PYTHON
-else
-	tox --develop -e $PYTHON -- -k "$FILTERS"
-fi