diff --git a/Lib/fontTools/feaLib/builder.py b/Lib/fontTools/feaLib/builder.py
index 4a7d95758..989f05e20 100644
--- a/Lib/fontTools/feaLib/builder.py
+++ b/Lib/fontTools/feaLib/builder.py
@@ -1005,7 +1005,8 @@ class Builder(object):
         assert lookup_name in self.named_lookups_, lookup_name
         self.cur_lookup_ = None
         lookup = self.named_lookups_[lookup_name]
-        self.add_lookup_to_feature_(lookup, self.cur_feature_name_)
+        if lookup is not None:  # skip empty named lookup
+            self.add_lookup_to_feature_(lookup, self.cur_feature_name_)
 
     def set_font_revision(self, location, revision):
         self.fontRevision_ = revision
diff --git a/Tests/feaLib/data/bug2276.ttx b/Tests/feaLib/data/bug2276.ttx
new file mode 100644
index 000000000..57902dafa
--- /dev/null
+++ b/Tests/feaLib/data/bug2276.ttx
@@ -0,0 +1,59 @@
+<?xml version="1.0" encoding="UTF-8"?>
+<ttFont sfntVersion="\x00\x01\x00\x00" ttLibVersion="4.22">
+
+  <GSUB>
+    <Version value="0x00010000"/>
+    <ScriptList>
+      <!-- ScriptCount=1 -->
+      <ScriptRecord index="0">
+        <ScriptTag value="DFLT"/>
+        <Script>
+          <DefaultLangSys>
+            <ReqFeatureIndex value="65535"/>
+            <!-- FeatureCount=2 -->
+            <FeatureIndex index="0" value="0"/>
+            <FeatureIndex index="1" value="1"/>
+          </DefaultLangSys>
+          <!-- LangSysCount=0 -->
+        </Script>
+      </ScriptRecord>
+    </ScriptList>
+    <FeatureList>
+      <!-- FeatureCount=2 -->
+      <FeatureRecord index="0">
+        <FeatureTag value="aalt"/>
+        <Feature>
+          <!-- LookupCount=1 -->
+          <LookupListIndex index="0" value="0"/>
+        </Feature>
+      </FeatureRecord>
+      <FeatureRecord index="1">
+        <FeatureTag value="ss01"/>
+        <Feature>
+          <!-- LookupCount=1 -->
+          <LookupListIndex index="0" value="1"/>
+        </Feature>
+      </FeatureRecord>
+    </FeatureList>
+    <LookupList>
+      <!-- LookupCount=2 -->
+      <Lookup index="0">
+        <LookupType value="1"/>
+        <LookupFlag value="0"/>
+        <!-- SubTableCount=1 -->
+        <SingleSubst index="0">
+          <Substitution in="a" out="a.alt1"/>
+        </SingleSubst>
+      </Lookup>
+      <Lookup index="1">
+        <LookupType value="1"/>
+        <LookupFlag value="0"/>
+        <!-- SubTableCount=1 -->
+        <SingleSubst index="0">
+          <Substitution in="a" out="a.alt1"/>
+        </SingleSubst>
+      </Lookup>
+    </LookupList>
+  </GSUB>
+
+</ttFont>