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Fixes crash when html has an xml version tag by stripping it out
2016-08-14 05:11:01 +00:00
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<title>Antihypertensive efficacy of the losartan/hydrochlorothiazide combination and its effect on plasma B-type natriuretic peptide in hypertensive patie... - PubMed - NCBI
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<script type="text/javascript" src="https://static.pubmed.gov/core/jig/1.14.8/js/jig.min.js"></script><meta name="author" content="Meno H , et al." /><meta name="description" content="Clin Drug Investig. 2012 Mar 1;32(3):171-8. doi: 10.2165/11597620-000000000-00000. Clinical Trial; Multicenter Study; Research Support, Non-U.S. Gov't" /><meta name="keywords" content="Adult;Aged;Angiotensin II Type 1 Receptor Blockers;Drug Therapy, Combination;Female;Humans;Hydrochlorothiazide;Hypertension;Losartan;Male;Middle Aged;Natriuretic Peptide, Brain;Prospective Studies" />
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<div class="rprt_all"><div class="rprt abstract"><a href="#comments" id="see_pmcommons">See comment in PubMed Commons below</a><div class="cit"><a href="#" title="Clinical drug investigation." abstractLink="yes" alsec="jour" alterm="Clin Drug Investig.">Clin Drug Investig.</a> 2012 Mar 1;32(3):171-8. doi: 10.2165/11597620-000000000-00000.</div><h1>Antihypertensive efficacy of the losartan/hydrochlorothiazide combination and its effect on plasma B-type natriuretic peptide in hypertensive patients uncontrolled by angiotensin II type 1 receptor antagonist-based therapy: a multicentre prospective observational study.</h1><div class="auths"><a href="/pubmed/?term=Meno%20H%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Meno H</a><sup>1</sup>, <a href="/pubmed/?term=Inou%20T%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Inou T</a>, <a href="/pubmed/?term=Tanaka%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Tanaka M</a>, <a href="/pubmed/?term=Tsuchiya%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Tsuchiya Y</a>, <a href="/pubmed/?term=Shiga%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Shiga Y</a>, <a href="/pubmed/?term=Kobayashi%20K%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Kobayashi K</a>, <a href="/pubmed/?term=Nakamura%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Nakamura Y</a>, <a href="/pubmed/?term=Ota%20T%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Ota T</a>, <a href="/pubmed/?term=Kubara%20I%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Kubara I</a>.</div><div class="afflist"><h3><a title="Open/close author information list" class="jig-ncbitoggler" href="#">Author information</a></h3><ul class="ui-ncbi-toggler-slave"><li><sup>1</sup>Department of Cardiology and Internal Medicine, Fukuoka Red Cross Hospital, Fukuoka, Japan. hiroshimeno@fukuoka-med.jrc.or.jp</li></ul></div><div class="abstr"><h3>Abstract</h3><div class=""><h4>BACKGROUND AND OBJECTIVES: </h4><p><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">Although strict blood pressure (BP) control is effective in the prevention of cardiovascular events, it is often insufficient in many hypertensive patients. B-type natriuretic peptide (BNP) has been shown to be associated with cardiovascular events. We investigated the effects of the losartan/hydrochlorothiazide combination on BP and plasma BNP in hypertensive patients uncontrolled by an angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB])-based therapy.</AbstractText></p><h4>METHODS: </h4><p><AbstractText Label="METHODS" NlmCategory="METHODS">In a multicentre prospective observational study, we enrolled 185 patients aged 36-79 years (mean age 63.8 years) with essential hypertension but without symptoms of heart failure who received an ARB-based therapy for ≥3 months but failed to achieve a target BP recommended by the Japanese Society of Hypertension (JSH). ARBs were switched to losartan (LOS) 50 mg/hydrochlorothiazide (HCTZ) 12.5 mg. The antihypertensive efficacy, safety, and effects of this combination on blood biochemical parameters and plasma BNP were evaluated for 12 months.</AbstractText></p><h4>RESULTS: </h4><p><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean ± SD systolic and diastolic BP decreased from 152 ± 13/87 ± 10 mmHg to 128 ± 14/74 ± 10 mmHg, respectively, after 12 months (p &lt; 0.001). Mean ± SD plasma BNP levels decreased significantly from 46.0 ± 83.0 pg/mL to 40.8 ± 68.0 pg/mL (p &lt; 0.05). The percentage of patients who achieved the JSH 2004 target BP was 51% after 12 months; the percentage was 63% in elderly patients aged ≥65 years without complications, and 43% in patients with concomitant diabetes mellitus or chronic kidney disease. No association was found between a decrease in plasma BNP levels and BP, age, body mass index or estimated glomerular filtration rate. There was a significant increase in serum uric acid and a decrease in serum potassium, but both w
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