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<title>Antihypertensive efficacy of the losartan/hydrochlorothiazide combination and its effect on plasma B-type natriuretic peptide in hypertensive patie... - PubMed - NCBI
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<script type="text/javascript" src="https://static.pubmed.gov/core/jig/1.14.8/js/jig.min.js"></script><meta name="author" content="Meno H , et al." /><meta name="description" content="Clin Drug Investig. 2012 Mar 1;32(3):171-8. doi: 10.2165/11597620-000000000-00000. Clinical Trial; Multicenter Study; Research Support, Non-U.S. Gov't" /><meta name="keywords" content="Adult;Aged;Angiotensin II Type 1 Receptor Blockers;Drug Therapy, Combination;Female;Humans;Hydrochlorothiazide;Hypertension;Losartan;Male;Middle Aged;Natriuretic Peptide, Brain;Prospective Studies" />
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<div class="rprt_all"><div class="rprt abstract"><a href="#comments" id="see_pmcommons">See comment in PubMed Commons below</a><div class="cit"><a href="#" title="Clinical drug investigation." abstractLink="yes" alsec="jour" alterm="Clin Drug Investig.">Clin Drug Investig.</a> 2012 Mar 1;32(3):171-8. doi: 10.2165/11597620-000000000-00000.</div><h1>Antihypertensive efficacy of the losartan/hydrochlorothiazide combination and its effect on plasma B-type natriuretic peptide in hypertensive patients uncontrolled by angiotensin II type 1 receptor antagonist-based therapy: a multicentre prospective observational study.</h1><div class="auths"><a href="/pubmed/?term=Meno%20H%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Meno H</a><sup>1</sup>, <a href="/pubmed/?term=Inou%20T%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Inou T</a>, <a href="/pubmed/?term=Tanaka%20M%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Tanaka M</a>, <a href="/pubmed/?term=Tsuchiya%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Tsuchiya Y</a>, <a href="/pubmed/?term=Shiga%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Shiga Y</a>, <a href="/pubmed/?term=Kobayashi%20K%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Kobayashi K</a>, <a href="/pubmed/?term=Nakamura%20Y%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Nakamura Y</a>, <a href="/pubmed/?term=Ota%20T%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Ota T</a>, <a href="/pubmed/?term=Kubara%20I%5BAuthor%5D&amp;cauthor=true&amp;cauthor_uid=22188593">Kubara I</a>.</div><div class="afflist"><h3><a title="Open/close author information list" class="jig-ncbitoggler" href="#">Author information</a></h3><ul class="ui-ncbi-toggler-slave"><li><sup>1</sup>Department of Cardiology and Internal Medicine, Fukuoka Red Cross Hospital, Fukuoka, Japan. hiroshimeno@fukuoka-med.jrc.or.jp</li></ul></div><div class="abstr"><h3>Abstract</h3><div class=""><h4>BACKGROUND AND OBJECTIVES: </h4><p><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">Although strict blood pressure (BP) control is effective in the prevention of cardiovascular events, it is often insufficient in many hypertensive patients. B-type natriuretic peptide (BNP) has been shown to be associated with cardiovascular events. We investigated the effects of the losartan/hydrochlorothiazide combination on BP and plasma BNP in hypertensive patients uncontrolled by an angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB])-based therapy.</AbstractText></p><h4>METHODS: </h4><p><AbstractText Label="METHODS" NlmCategory="METHODS">In a multicentre prospective observational study, we enrolled 185 patients aged 36-79 years (mean age 63.8 years) with essential hypertension but without symptoms of heart failure who received an ARB-based therapy for ≥3 months but failed to achieve a target BP recommended by the Japanese Society of Hypertension (JSH). ARBs were switched to losartan (LOS) 50mg/hydrochlorothiazide (HCTZ) 12.5mg. The antihypertensive efficacy, safety, and effects of this combination on blood biochemical parameters and plasma BNP were evaluated for 12 months.</AbstractText></p><h4>RESULTS: </h4><p><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean±SD systolic and diastolic BP decreased from 152±13/87±10mmHg to 128±14/74±10mmHg, respectively, after 12 months (p&lt;0.001). Mean±SD plasma BNP levels decreased significantly from 46.0±83.0pg/mL to 40.8±68.0pg/mL (p&lt;0.05). The percentage of patients who achieved the JSH 2004 target BP was 51% after 12 months; the percentage was 63% in elderly patients aged ≥65 years without complications, and 43% in patients with concomitant diabetes mellitus or chronic kidney disease. No association was found between a decrease in plasma BNP levels and BP, age, body mass index or estimated glomerular filtration rate. There was a significant increase in serum uric acid and a decrease in serum potassium, but both were within the range of normal values. Adverse events were observed in 8.6% of the patients.</AbstractText></p><h4>CONCLUSION: </h4><p><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Antihypertensive treatment using two types of drugs (LOS/HCTZ) with different mechanisms yielded potent antihypertensive efficacy with safety and decreased plasma BNP levels.</AbstractText></p></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMID:</dt> <dd><a href="/pubmed/22188593" ref="aid_type=pmid">22188593</a></dd> <dt>DOI:</dt> <dd><a href="//dx.doi.org/10.2165/11597620-000000000-00000" ref="aid_type=doi">10.2165/11597620-000000000-00000</a></dd> </dl></div><div class="resc status"><dl class="rprtid"><dd> [PubMed - indexed for MEDLINE] </dd></dl></div><div class="links"></div><div id="ncbi_share_pm"><a href="#" class="ncbi_share" style="visibility:hidden" data-ncbi_share_config="popup:false,shorten:true" ref="id=22188593&amp;db=pubmed">Share</a></div></div><div class="morecit"><h3><a title="Supplemental information" class="jig-ncbitoggler ui-ncbitoggler" href="#"><span class="ui-ncbitoggler-master-text">Publication Types, MeSH Terms, Substances</span><span class="ui-icon ui-icon-triangle-1-e"></span></a></h3><div class="ui-ncbi-toggler-slave"><h4>Publication Types</h4><ul><li><a href="#" abstractLink="yes" alsec="ptyp" alterm="Clinical Trial">Clinical Trial</a></li><li><a href="#" abstractLink="yes" alsec="ptyp" alterm="Multicenter Study">Multicenter Study</a></li><li><a href="#" abstractLink="yes" alsec="ptyp" alterm="Research Support, Non-U.S. Gov't">Research Support, Non-U.S. Gov't</a></li></ul><h4>MeSH Terms</h4><ul><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Adult">Adult</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Aged">Aged</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Angiotensin II Type 1 Receptor Blockers/administration &amp; dosage*">Angiotensin II Type 1 Receptor Blockers/administration &amp; dosage*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Drug Therapy, Combination">Drug Therapy, Combination</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Female">Female</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Humans">Humans</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Hydrochlorothiazide/administration &amp; dosage*">Hydrochlorothiazide/administration &amp; dosage*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Hypertension/blood">Hypertension/blood</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Hypertension/drug therapy*">Hypertension/drug therapy*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Losartan/administration &amp; dosage*">Losartan/administration &amp; dosage*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Male">Male</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Middle Aged">Middle Aged</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Natriuretic Peptide, Brain/blood*">Natriuretic Peptide, Brain/blood*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Prospective Studies">Prospective Studies</a></li></ul><h4>Substances</h4><ul><li><a href="#" abstractLink="yes" alsec="subs" alterm="Angiotensin II Type 1 Receptor Blockers">Angiotensin II Type 1 Receptor Blockers</a></li><li><a href="#" abstractLink="yes" alsec="subs" alterm="Hydrochlorothiazide">Hydrochlorothiazide</a></li><li><a href="#" abstractLink="yes" alsec="subs" alterm="Natriuretic Peptide, Brain">Natriuretic Peptide, Brain</a></li><li><a href="#" abstractLink="yes" alsec="subs" alterm="Losartan">Losartan</a></li></ul></div></div><div class="morecit"><h3><a title="Links to resources such as full text articles and biological data" class="jig-ncbitoggler ui-ncbitoggler" href="#"><span class="ui-ncbitoggler-master-text">LinkOut - more resources</span><span class="ui-icon ui-icon-triangle-1-e"></span></a></h3><div class="ui-ncbi-toggler-slave"><div class="linkoutlist"><h4>Full Text Sources</h4><ul><li><a title="Full text at publisher's site" href="http://dx.doi.org/10.2165/11597620-000000000-00000" ref="itool=Abstract&amp;PrId=3055&amp;uid=22188593&amp;db=pubmed&amp;log$=linkoutlink&amp;nlmid=9504817" target="_blank">Springer</a></li><li><a href="http://ovidsp.ovid.com/ovidweb.cgi?T=JS&amp;PAGE=linkout&amp;SEARCH=22188593.ui" ref="itool=Abstract&amp;PrId=3682&amp;uid=22188593&amp;db=pubmed&amp;log$=linkoutlink&amp;nlmid=9504817" target="_blank">Ovid Technologies, Inc.</a></li></ul><h4>Medical</h4><ul><li><a title="Free resource" href="https://medlineplus.gov/highbloodpressure.html" ref="itool=Abstract&amp;PrId=3162&amp;uid=22188593&amp;db=pubmed&amp;log$=linkoutlink&amp;nlmid=9504817" target="_blank">High Blood Pressure - MedlinePlus Health Information</a></li></ul><h4>Miscellaneous</h4><ul><li><a title="Free resource" href="https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+58-93-5" ref="itool=Abstract&amp;PrId=4419&amp;uid=22188593&amp;db=pubmed&amp;log$=linkoutlink&amp;nlmid=9504817" target="_blank">HYDROCHLOROTHIAZIDE - Hazardous Substances Data Bank</a></li><li><a title="Free resource" href="https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+114798-26-4" ref="itool=Abstract&amp;PrId=4419&amp;uid=22188593&amp;db=pubmed&amp;log$=linkoutlink&amp;nlmid=9504817" target="_blank">Losartan - Hazardous Substances Data Bank</a></li></ul></div></div></div><div id="comments_panel" data-recid="22188593" data-exp="true" data-rsys="1"><div id="comments_panel_head"><a id="coments_panel_anchor" href="/pubmedcommons/" name="comments">PubMed Commons home</a><h2><span id="show_comments" title="Shows comments">
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