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">Trace Archive</a></li><li><a href="/unigene" title=" Gene-centered clusters of transcripts and ESTs ">UniGene</a></li><li><a href="/guide/dna-rna/">All DNA & RNA Resources...</a></li></ul></li><li><a href="#data-software">Data & Software</a><ul class="actual-resources-submenu data-software"><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi" title=" Tool for finding local regions of sequence similarity ">BLAST (Basic Local Alignment Search Tool)</a></li><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=Download" title=" BLAST programs for a local computer ">BLAST (Stand-alone)</a></li><li><a href="/Structure/CN3D/cn3d.shtml" title=" Program for viewing 3D structures and alignments ">Cn3D</a></li><li><a href="/Structure/cdd/wrpsb.cgi" title=" Locates conserved domains within a protein sequence ">Conserved Domain Search Service (CD Search)</a></li><li><a href="/books/NBK25501/ " title=" URL application programming interface for searching, linking and downloading data within NCBI's Entrez system ">E-Utilities</a></li><li><a href="/WebSub/?tool=genbank" title=" Web tool for simple submissions of nucleotide sequences ">GenBank: BankIt</a></li><li><a href="/projects/Sequin/" title=" Software tool for complex submissions of nucleotide sequences ">GenBank: Sequin</a></li><li><a href="/genbank/tbl2asn2/" title=" Command-line program for submitting sequence data ">GenBank: tbl2asn</a></li><li><a href="/sutils/protmap.cgi" title=" Maps proteins from a COG/VOG back to its genome ">Genome ProtMap</a></li><li><a href="/tools/gbench/" title=" Stand-alone application for analyzing sequence data ">Genome Workbench</a></li><li><a href="/tools/primer-blast/" title=" Designs PCR primers and analyzes them for target specificity using BLAST. ">Primer-BLAST</a></li><li><a href="/sutils/static/prosplign/prosplign.html" title=" Tool for aligning proteins to genomic DNA ">ProSplign</a></li><li><a href="https://pubchem.ncbi.nlm.nih.gov/search/search.cgi" title=" Searches PubChem Compound by chemical structure ">PubChem Structure Search</a></li><li><a href="/projects/SNP/" title=" The SNP database tools page provides links to the general submission guidelines and to the submission handle request. ">SNP Submission Tool</a></li><li><a href="/sutils/splign/" title=" Tool for aligning transcripts to genomic DNA ">Splign</a></li><li><a href="/Structure/VAST/vast.html" title=" Tool that generates 3D structural alignments ">Vector Alignment Search Tool (VAST)</a></li><li><a href="/guide/data-software/">All Data & Software Resources...</a></li></ul></li><li><a href="#domains-structures">Domains & Structures</a><ul class="actual-resources-submenu domains-structures"><li><a href="/biosystems/" title=" Database that groups biomedical literature, small molecules, and sequence data in terms of biological relationships. ">BioSystems</a></li><li><a href="/Structure/CN3D/cn3d.shtml" title=" Program for viewing 3D structures and alignments ">Cn3D</a></li><li><a href="/cdd" title=" Database of conserved protein domains represented by multiple sequence alignments ">Conserved Domain Database (CDD)</a></li><li><a href="/Structure/cdd/wrpsb.cgi" title=" Locates conserved domains within a protein sequence ">Conserved Domain Search Service (CD Search)</a></li><li><a href="/structure/" title=" Database of 3D macromolecular structures derived from PDB ">Structure (Molecular Modeling Database)</a></li><li><a href="/Structure/VAST/vast.html" title=" Tool that generates 3D structural alignments ">Vector Alignment Search Tool (VAST)</a></li><li><a href="/guide/domains-structures/">All Domains & Structures Resources...</a></li></ul></li><li><a href="#genes-expression">Genes & Expression</a><ul class="actual-resources-submenu genes-expression"><li><a href="/biosystems/" title=" Database that groups biomedical literature, small molecules, and sequence data in terms of biological relationships. ">BioSystems</a></li><li><a href="/gap" title=" Genotype/Phenotype association studies ">Database of Genotypes and Phenotypes (dbGaP)</a></li><li><a href="/books/NBK25501/ " title=" URL application programming interface for searching, linking and downloading data within NCBI's Entrez system ">E-Utilities</a></li><li><a href="/gene" title=" Database of gene loci and associated transcripts and proteins ">Gene</a></li><li><a href="/geo/" title=" Gene Expression Omnibus (GEO) Database ">Gene Expression Omnibus (GEO) Database </a></li><li><a href="/gds" title=" Curated collections of gene expression data sets ">Gene Expression Omnibus (GEO) Datasets</a></li><li><a href="/geoprofiles/" title=" Database of gene expression Profiles for individual sequences ">Gene Expression Omnibus (GEO) Profiles</a></li><li><a href="/tools/gbench/" title=" Stand-alone application for analyzing sequence data ">Genome Workbench</a></li><li><a href="/homologene" title=" Sets of homologous eukaryotic genes ">HomoloGene</a></li><li><a href="/mapview/" title=" Tool for searching, viewing and downloading genomic maps and related data ">Map Viewer</a></li><li><a href="/omim" title=" Database of human genes and genetic disorders ">Online Mendelian Inheritance in Man (OMIM)</a></li><li><a href="/refseq/rsg/" title=" RefSeqGene reference standards for genomic sequences of well-characterized genes ">RefSeqGene</a></li><li><a href="/unigene" title=" Gene-centered clusters of transcripts and ESTs ">UniGene</a></li><li><a href="/guide/genes-expression/">All Genes & Expression Resources...</a></li></ul></li><li><a href="#genetics-medicine">Genetics & Medicine</a><ul class="actual-resources-submenu genetics-medicine"><li><a href="/books" title=" Online biomedical books ">Bookshelf</a></li><li><a href="/gap" title=" Genotype/Phenotype association studies ">Database of Genotypes and Phenotypes (dbGaP)</a></li><li><a href="/gtr/" title=" Detailed information about genetic tests and labs ">Genetic Testing Registry</a></li><li><a href="/genomes/FLU/" title=" Data from the NIAID Influenza Genome Sequencing Project ">Influenza Virus</a></li><li><a href="/mapview/" title=" Tool for searching, viewing and downloading genomic maps and related data ">Map Viewer</a></li><li><a href="/omim" title=" Database of human genes and genetic disorders ">Online Mendelian Inheritance in Man (OMIM)</a></li><li><a href="/pubmed" title=" Biomedical literature abstracts ">PubMed</a></li><li><a href="/pmc/" title=" Free, full-text articles ">PubMed Central (PMC)</a></li><li><a href="/pubmed/clinical " title=" Directory of PubMed queries about clinical topics ">PubMed Clinical Queries</a></li><li><a href="/refseq/rsg/" title=" RefSeqGene reference standards for genomic sequences of well-characterized genes ">RefSeqGene</a></li><li><a href="/guide/genetics-medicine/">All Genetics & Medicine Resources...</a></li></ul></li><li><a href="#genomes-maps">Genomes & Maps</a><ul class="actual-resources-submenu genomes-maps"><li><a href="/dbvar" title=" A database of genomic structural variation ">Database of Genomic Structural Variation (dbVar)</a></li><li><a href="/genbank/tbl2asn2/" title=" Command-line program for submitting sequence data ">GenBank: tbl2asn</a></li><li><a href="/sites/genome" title=" Curated genomic DNA sequences ">Genome</a></li><li><a href="/bioproject/" title=" Central status pages for genome sequencing projects ">Genome Project</a></li><li><a href="/sutils/protmap.cgi" title=" Maps proteins from a COG/VOG back to its genome ">Genome ProtMap</a></li><li><a href="/tools/gbench/" title=" Stand-alone application for analyzing sequence data ">Genome Workbench</a></li><li><a href="/genomes/FLU/" title=" Data from the NIAID Influenza Genome Sequencing Project ">Influenza Virus</a></li><li><a href="/mapview/" title=" Tool for searching, viewing and downloading genomic maps and related data ">Map Viewer</a></li><li><a href="/nuccore" title=" Nucleotide sequence data in GenBank and RefSeq ">Nucleotide Database</a></li><li><a href="/popset" title=" Sets of nucleotide sequences representing a population ">PopSet</a></li><li><a href="/sutils/static/prosplign/prosplign.html" title=" Tool for aligning proteins to genomic DNA ">ProSplign</a></li><li><a href="/Traces/sra/sra.cgi?" title=" Database of sequences reads from next generation sequencing technologies ">Sequence Read Archive (SRA)</a></li><li><a href="/sutils/splign/" title=" Tool for aligning transcripts to genomic DNA ">Splign</a></li><li><a href="/Traces/trace.cgi" title=" DNA chromatograms, base calls, and quality estimates for single-pass reads. ">Trace Archive</a></li><li><a href="/guide/genomes-maps/">All Genomes & Maps Resources...</a></li></ul></li><li><a href="#homology">Homology</a><ul class="actual-resources-submenu homology"><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi" title=" Tool for finding local regions of sequence similarity ">BLAST (Basic Local Alignment Search Tool)</a></li><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=Download" title=" BLAST programs for a local computer ">BLAST (Stand-alone)</a></li><li><a href="/sutils/blink.cgi?mode=query" title=" Pre-computed reports showing proteins with similar sequences ">BLAST Link (BLink)</a></li><li><a href="/cdd" title=" Database of conserved protein domains represented by multiple sequence alignments ">Conserved Domain Database (CDD)</a></li><li><a href="/Structure/cdd/wrpsb.cgi" title=" Locates conserved domains within a protein sequence ">Conserved Domain Search Service (CD Search)</a></li><li><a href="/sutils/protmap.cgi" title=" Maps proteins from a COG/VOG back to its genome ">Genome ProtMap</a></li><li><a href="/homologene" title=" Sets of homologous eukaryotic genes ">HomoloGene</a></li><li><a href="/proteinclusters" title=" Clusters of related proteins from prokaryotes and organelles ">Protein Clusters</a></li><li><a href="/guide/homology/">All Homology Resources...</a></li></ul></li><li><a href="#literature">Literature</a><ul class="actual-resources-submenu literature"><li><a href="/books" title=" Online biomedical books ">Bookshelf</a></li><li><a href="/books/NBK25501/ " title=" URL application programming interface for searching, linking and downloading data within NCBI's Entrez system ">E-Utilities</a></li><li><a href="/nlmcatalog/journals" title=" Information on journals cited by NCBI records ">Journals in NCBI Databases</a></li><li><a href="/mesh" title=" Controlled vocabulary for MEDLINE ">MeSH Database</a></li><li><a href="/books/NBK143764/" title=" Introductory articles about NCBI resources ">NCBI Handbook</a></li><li><a href="/books/NBK3831/" title=" Online, searchable help documentation ">NCBI Help Manual</a></li><li><a href="/books/NBK1969/" title=" NCBI's monthly newsletter ">NCBI News</a></li><li><a href="/pubmed" title=" Biomedical literature abstracts ">PubMed</a></li><li><a href="/pmc/" title=" Free, full-text articles ">PubMed Central (PMC)</a></li><li><a href="/pubmed/clinical " title=" Directory of PubMed queries about clinical topics ">PubMed Clinical Queries</a></li><li><a href="/pubmedhealth/" title=" Reviews of clinical effectiveness research ">PubMed Health</a></li><li><a href="/guide/literature/">All Literature Resources...</a></li></ul></li><li><a href="#proteins">Proteins</a><ul class="actual-resources-submenu proteins"><li><a href="/biosystems/" title=" Database that groups biomedical literature, small molecules, and sequence data in terms of biological relationships. ">BioSystems</a></li><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi" title=" Tool for finding local regions of sequence similarity ">BLAST (Basic Local Alignment Search Tool)</a></li><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=Download" title=" BLAST programs for a local computer ">BLAST (Stand-alone)</a></li><li><a href="/sutils/blink.cgi?mode=query" title=" Pre-computed reports showing proteins with similar sequences ">BLAST Link (BLink)</a></li><li><a href="/cdd" title=" Database of conserved protein domains represented by multiple sequence alignments ">Conserved Domain Database (CDD)</a></li><li><a href="/Structure/cdd/wrpsb.cgi" title=" Locates conserved domains within a protein sequence ">Conserved Domain Search Service (CD Search)</a></li><li><a href="/books/NBK25501/ " title=" URL application programming interface for searching, linking and downloading data within NCBI's Entrez system ">E-Utilities</a></li><li><a href="/sutils/static/prosplign/prosplign.html" title=" Tool for aligning proteins to genomic DNA ">ProSplign</a></li><li><a href="/proteinclusters" title=" Clusters of related proteins from prokaryotes and organelles ">Protein Clusters</a></li><li><a href="/protein" title=" Protein sequence data ">Protein Database</a></li><li><a href="/refseq/" title=" Curated nucleotide and protein sequences produced by NCBI ">Reference Sequence (RefSeq)</a></li><li><a href="/guide/proteins/">All Proteins Resources...</a></li></ul></li><li><a href="#sequence-analysis">Sequence Analysis</a><ul class="actual-resources-submenu sequence-analysis"><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi" title=" Tool for finding local regions of sequence similarity ">BLAST (Basic Local Alignment Search Tool)</a></li><li><a href="https://blast.ncbi.nlm.nih.gov/Blast.cgi?CMD=Web&PAGE_TYPE=BlastDocs&DOC_TYPE=Download" title=" BLAST programs for a local computer ">BLAST (Stand-alone)</a></li><li><a href="/sutils/blink.cgi?mode=query" title=" Pre-computed reports showing proteins with similar sequences ">BLAST Link (BLink)</a></li><li><a href="/Structure/cdd/wrpsb.cgi" title=" Locates conserved domains within a protein sequence ">Conserved Domain Search Service (CD Search)</a></li><li><a href="/sutils/protmap.cgi" title=" Maps proteins from a COG/VOG back to its genome ">Genome ProtMap</a></li><li><a href="/tools/gbench/" title=" Stand-alone application for analyzing sequence data ">Genome Workbench</a></li><li><a href="/genomes/FLU/" title=" Data from the NIAID Influenza Genome Sequencing Project ">Influenza Virus</a></li><li><a href="/tools/primer-blast/" title=" Designs PCR primers and analyzes them for target specificity using BLAST. ">Primer-BLAST</a></li><li><a href="/sutils/static/prosplign/prosplign.html" title=" Tool for aligning proteins to genomic DNA ">ProSplign</a></li><li><a href="/sutils/splign/" title=" Tool for aligning transcripts to genomic DNA ">Splign</a></li><li><a href="/guide/sequence-analysis/">All Sequence Analysis Resources...</a></li></ul></li><li><a href="#taxonomy">Taxonomy</a><ul class="actual-resources-submenu taxonomy"><li><a href="/taxonomy" title=" The NCBI taxonomy tree in Entrez ">Taxonomy</a></li><li><a href="/Taxonomy/Browser/wwwtax.cgi?mode=Root" title=" Displays and links Entrez data to each taxonomic node ">Taxonomy Browser</a></li><li><a href="/Taxonomy/CommonTree/wwwcmt.cgi" title=" Creates custom taxonomic trees ">Taxonomy Common Tree</a></li><li><a href="/guide/taxonomy/">All Taxonomy Resources...</a></li></ul></li><li><a href="#training-tutorials">Training & Tutorials</a><ul class="actual-resources-submenu training-tutorials"><li><a href="/education/" title=" Central page providing links to tutorials and training materials ">NCBI Education Page</a></li><li><a href="/books/NBK143764/" title=" Introductory articles about NCBI resources ">NCBI Handbook</a></li><li><a href="/books/NBK3831/" title=" Online, searchable help documentation ">NCBI Help Manual</a></li><li><a href="/books/NBK1969/" title=" NCBI's monthly newsletter ">NCBI News</a></li><li><a href="/guide/training-tutorials/">All Training & Tutorials Resources...</a></li></ul></li><li><a href="#variation">Variation</a><ul class="actual-resources-submenu variation"><li><a href="/dbvar" title=" A database of genomic structural variation ">Database of Genomic Structural Variation (dbVar)</a></li><li><a href="/gap" title=" Genotype/Phenotype association studies ">Database of Genotypes and Phenotypes (dbGaP)</a></li><li><a href="/snp" title=" Database of nucleotide sequence polymorphisms ">Database of Single Nucleotide Polymorphisms (dbSNP)</a></li><li><a href="/projects/SNP/" title=" The SNP database tools page provides links to the general submission guidelines and to the submission handle request. 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<div class="rprt_all"><div class="rprt abstract"><a href="#comments" id="see_pmcommons">See comment in PubMed Commons below</a><div class="cit"><a href="#" title="Clinical drug investigation." abstractLink="yes" alsec="jour" alterm="Clin Drug Investig.">Clin Drug Investig.</a> 2012 Mar 1;32(3):171-8. doi: 10.2165/11597620-000000000-00000.</div><h1>Antihypertensive efficacy of the losartan/hydrochlorothiazide combination and its effect on plasma B-type natriuretic peptide in hypertensive patients uncontrolled by angiotensin II type 1 receptor antagonist-based therapy: a multicentre prospective observational study.</h1><div class="auths"><a href="/pubmed/?term=Meno%20H%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Meno H</a><sup>1</sup>, <a href="/pubmed/?term=Inou%20T%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Inou T</a>, <a href="/pubmed/?term=Tanaka%20M%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Tanaka M</a>, <a href="/pubmed/?term=Tsuchiya%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Tsuchiya Y</a>, <a href="/pubmed/?term=Shiga%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Shiga Y</a>, <a href="/pubmed/?term=Kobayashi%20K%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Kobayashi K</a>, <a href="/pubmed/?term=Nakamura%20Y%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Nakamura Y</a>, <a href="/pubmed/?term=Ota%20T%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Ota T</a>, <a href="/pubmed/?term=Kubara%20I%5BAuthor%5D&cauthor=true&cauthor_uid=22188593">Kubara I</a>.</div><div class="afflist"><h3><a title="Open/close author information list" class="jig-ncbitoggler" href="#">Author information</a></h3><ul class="ui-ncbi-toggler-slave"><li><sup>1</sup>Department of Cardiology and Internal Medicine, Fukuoka Red Cross Hospital, Fukuoka, Japan. hiroshimeno@fukuoka-med.jrc.or.jp</li></ul></div><div class="abstr"><h3>Abstract</h3><div class=""><h4>BACKGROUND AND OBJECTIVES: </h4><p><AbstractText Label="BACKGROUND AND OBJECTIVES" NlmCategory="OBJECTIVE">Although strict blood pressure (BP) control is effective in the prevention of cardiovascular events, it is often insufficient in many hypertensive patients. B-type natriuretic peptide (BNP) has been shown to be associated with cardiovascular events. We investigated the effects of the losartan/hydrochlorothiazide combination on BP and plasma BNP in hypertensive patients uncontrolled by an angiotensin II type 1 receptor antagonist (angiotensin receptor blocker [ARB])-based therapy.</AbstractText></p><h4>METHODS: </h4><p><AbstractText Label="METHODS" NlmCategory="METHODS">In a multicentre prospective observational study, we enrolled 185 patients aged 36-79 years (mean age 63.8 years) with essential hypertension but without symptoms of heart failure who received an ARB-based therapy for ≥3 months but failed to achieve a target BP recommended by the Japanese Society of Hypertension (JSH). ARBs were switched to losartan (LOS) 50 mg/hydrochlorothiazide (HCTZ) 12.5 mg. The antihypertensive efficacy, safety, and effects of this combination on blood biochemical parameters and plasma BNP were evaluated for 12 months.</AbstractText></p><h4>RESULTS: </h4><p><AbstractText Label="RESULTS" NlmCategory="RESULTS">Mean ± SD systolic and diastolic BP decreased from 152 ± 13/87 ± 10 mmHg to 128 ± 14/74 ± 10 mmHg, respectively, after 12 months (p < 0.001). Mean ± SD plasma BNP levels decreased significantly from 46.0 ± 83.0 pg/mL to 40.8 ± 68.0 pg/mL (p < 0.05). The percentage of patients who achieved the JSH 2004 target BP was 51% after 12 months; the percentage was 63% in elderly patients aged ≥65 years without complications, and 43% in patients with concomitant diabetes mellitus or chronic kidney disease. No association was found between a decrease in plasma BNP levels and BP, age, body mass index or estimated glomerular filtration rate. There was a significant increase in serum uric acid and a decrease in serum potassium, but both were within the range of normal values. Adverse events were observed in 8.6% of the patients.</AbstractText></p><h4>CONCLUSION: </h4><p><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Antihypertensive treatment using two types of drugs (LOS/HCTZ) with different mechanisms yielded potent antihypertensive efficacy with safety and decreased plasma BNP levels.</AbstractText></p></div></div><div class="aux"><div class="resc"><dl class="rprtid"><dt>PMID:</dt> <dd><a href="/pubmed/22188593" ref="aid_type=pmid">22188593</a></dd> <dt>DOI:</dt> <dd><a href="//dx.doi.org/10.2165/11597620-000000000-00000" ref="aid_type=doi">10.2165/11597620-000000000-00000</a></dd> </dl></div><div class="resc status"><dl class="rprtid"><dd> [PubMed - indexed for MEDLINE] </dd></dl></div><div class="links"></div><div id="ncbi_share_pm"><a href="#" class="ncbi_share" style="visibility:hidden" data-ncbi_share_config="popup:false,shorten:true" ref="id=22188593&db=pubmed">Share</a></div></div><div class="morecit"><h3><a title="Supplemental information" class="jig-ncbitoggler ui-ncbitoggler" href="#"><span class="ui-ncbitoggler-master-text">Publication Types, MeSH Terms, Substances</span><span class="ui-icon ui-icon-triangle-1-e"></span></a></h3><div class="ui-ncbi-toggler-slave"><h4>Publication Types</h4><ul><li><a href="#" abstractLink="yes" alsec="ptyp" alterm="Clinical Trial">Clinical Trial</a></li><li><a href="#" abstractLink="yes" alsec="ptyp" alterm="Multicenter Study">Multicenter Study</a></li><li><a href="#" abstractLink="yes" alsec="ptyp" alterm="Research Support, Non-U.S. Gov't">Research Support, Non-U.S. Gov't</a></li></ul><h4>MeSH Terms</h4><ul><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Adult">Adult</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Aged">Aged</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Angiotensin II Type 1 Receptor Blockers/administration & dosage*">Angiotensin II Type 1 Receptor Blockers/administration & dosage*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Drug Therapy, Combination">Drug Therapy, Combination</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Female">Female</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Humans">Humans</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Hydrochlorothiazide/administration & dosage*">Hydrochlorothiazide/administration & dosage*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Hypertension/blood">Hypertension/blood</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Hypertension/drug therapy*">Hypertension/drug therapy*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Losartan/administration & dosage*">Losartan/administration & dosage*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Male">Male</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Middle Aged">Middle Aged</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Natriuretic Peptide, Brain/blood*">Natriuretic Peptide, Brain/blood*</a></li><li><a href="#" abstractLink="yes" alsec="mesh" alterm="Prospective Studies">Prospective Studies</a></li></ul><h4>Substances</h4><ul><li><a href="#" abstractLink="yes" alsec="subs" alterm="Angiotensin II Type 1 Receptor Blockers">Angiotensin II Type 1 Receptor Blockers</a></li><li><a href="#" abstractLink="yes" alsec="subs" alterm="Hydrochlorothiazide">Hydrochlorothiazide</a></li><li><a href="#" abstractLink="yes" alsec="subs" alterm="Natriuretic Peptide, Brain">Natriuretic Peptide, Brain</a></li><li><a href="#" abstractLink="yes" alsec="subs" alterm="Losartan">Losartan</a></li></ul></div></div><div class="morecit"><h3><a title="Links to resources such as full text articles and biological data" class="jig-ncbitoggler ui-ncbitoggler" href="#"><span class="ui-ncbitoggler-master-text">LinkOut - more resources</span><span class="ui-icon ui-icon-triangle-1-e"></span></a></h3><div class="ui-ncbi-toggler-slave"><div class="linkoutlist"><h4>Full Text Sources</h4><ul><li><a title="Full text at publisher's site" href="http://dx.doi.org/10.2165/11597620-000000000-00000" ref="itool=Abstract&PrId=3055&uid=22188593&db=pubmed&log$=linkoutlink&nlmid=9504817" target="_blank">Springer</a></li><li><a href="http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=22188593.ui" ref="itool=Abstract&PrId=3682&uid=22188593&db=pubmed&log$=linkoutlink&nlmid=9504817" target="_blank">Ovid Technologies, Inc.</a></li></ul><h4>Medical</h4><ul><li><a title="Free resource" href="https://medlineplus.gov/highbloodpressure.html" ref="itool=Abstract&PrId=3162&uid=22188593&db=pubmed&log$=linkoutlink&nlmid=9504817" target="_blank">High Blood Pressure - MedlinePlus Health Information</a></li></ul><h4>Miscellaneous</h4><ul><li><a title="Free resource" href="https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+58-93-5" ref="itool=Abstract&PrId=4419&uid=22188593&db=pubmed&log$=linkoutlink&nlmid=9504817" target="_blank">HYDROCHLOROTHIAZIDE - Hazardous Substances Data Bank</a></li><li><a title="Free resource" href="https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/r?dbs+hsdb:@term+@rn+114798-26-4" ref="itool=Abstract&PrId=4419&uid=22188593&db=pubmed&log$=linkoutlink&nlmid=9504817" target="_blank">Losartan - Hazardous Substances Data Bank</a></li></ul></div></div></div><div id="comments_panel" data-recid="22188593" data-exp="true" data-rsys="1"><div id="comments_panel_head"><a id="coments_panel_anchor" href="/pubmedcommons/" name="comments">PubMed Commons home</a><h2><span id="show_comments" title="Shows comments">
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